TSDS | Target-Scoped Decision System
Most targets -
and most molecules against them - should not proceed.
TSDS is a governed target-to-asset decision system for difficult drug discovery programs. It begins with target permission and extends into molecule-level progression, helping teams decide which targets, molecules, and execution paths should proceed, pause, or stop.
Constraint precedes selection. Evidence governs progression.
Failure Begins Before the Molecule Fails
Weak Biology
Biology that cannot support durable, meaningful impact
False Tractability
The problem is harder than it appears
Molecule Drift
Programs drift off intent without clear correction
TSDS does not select by preference.
It eliminates what cannot meet proof.
Only what survives constraint and evidence is allowed forward.
TWO CONNECTED DECISION LAYERS
01.
Target Permission
- Is the biology credible and compelling?
- Can constraints be survived?
- Is the modality fit-for-purpose?
- Can the outcome be measured?
02.
Molecule Progression
- Which molecules should proceed?
- Which should be held for more data?
- Which should stop now?
- Which require re-baselining?
A Target may earn permission. Individual molecules still have to earn progression.
FROM TARGET PERMISSION TO ASSET PROGRESSION.
Target Permission
Molecule Set
Evidence Mapping
Progression Decision
Execution Write-back
DECISION STATES
PROCEED
Strong Evidence, Advance, forward
PAUSE
Insufficient Evidence;
Gather more
STOP
Unrecoverable Risk,
Do not advance
Re-Baseline
Assumptions / strategy must be reset before further progression
Partner- Only
Internal progression stops; external partnership may remain possible
WHAT A TSDS ENGAGEMENT PRODUCES.
Target Permission
A clear, evidence-backed permission decision.
Constraint Register
Explicit constraints and survivability boundaries.
Evidence Map
Evidence links, quality, sufficiency, and decision relevance
Molecule Progression Map
A molecule-level progression map with decisions and rationale.
Decision Receipts
Traceable records showing what decision was made, why, and what evidence supported it.
Board Decision Sheet
Executive ready summary for governance review.